
Is a rapid change in treatment course detrimental?
Since nerves are susceptible to change, pain is beholden, as well. Slower or no transitions from one state of alert to another is preferred by both entities. As such, what may seem like reasonable treatment at the time may, by virtue of starting and stopping a pain treatment, startle the condition of calm into one of unrest, and therefore aggravation or pain. An example, gabapentin should not be stopped abruptly because it can take a relaxed nerve to an agitated state. Just as some medicines should not be fluctuated or used with alcohol, especially in significant concentrations or volumes should be avoided.

As with any central nervous system depressant, of which alcohol is a depressant, serious side effects may occur, especially in someone simultaneously struggling to balance pain cycles and medicines with their associated physical and emotional challenges. Thus, slow gradual adjustments should be made to any pain management plan.